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2022, Vol. 26 ›› Issue (1): 101-105Effects of miRNA in self-renewal, multidirectional differentiation, fate and function regulation of bone marrow mesenchymal stem cellsCui Shuaishuai1, Yang Xiaohong2
Abstract: BACKGROUND: Studies have confirmed that miRNAs are involved in self-renewal, multidirectional differentiation, fate determination, functional exercise and other aspects of bone marrow mesenchymal stem cells, and have become a hot spot in the medical field. OBJECTIVE: To review regulatory effect of miRNAs on bone marrow mesenchymal stem cells and its possible molecular mechanism. METHODS: PubMed was retrieved with the key words of “BMSCs, miRNA, proliferation, osteogenic differentiation, adipogenic differentiation, chondrogenic differentiation” in English. The retrieval time was from 2011 to 2021. After initial screening of titles and abstracts, irrelevant articles were excluded, and 51 eligible articles were included for result analysis. RESULTS AND CONCLUSION: miRNA plays an important role by targeting major genes and signaling pathways related to osteogenic differentiation, adipogenic differentiation, and chondrogenic differentiation. A large number of miRNAs have been shown to be associated with bone metabolic diseases such as osteoporosis and osteoarthritis, which seriously affect the quality of life of patients and impose a heavy burden on society. Therefore, more in-depth research and exploration on miRNAs and a better understanding of the regulation of the expression of these miRNAs will contribute to the development of targeted therapies for bone metabolism related diseases. Key words:stem cells, bone marrow mesenchymal stem cells, miRNA, proliferation, differentiation, review |