2022, Vol. 26 ›› Issue (1): 106-111

Biological function of circular RNAs in osteogenic differentiation of mesenchymal stem cells

Kang Yue1, Liu Jie2   

Abstract: BACKGROUND: Circular RNAs (circRNAs) were initially regarded as by-products of aberrant splicing. Present research on their mechanism has gradually penetrated to the molecular level. Many studies have shown that circRNAs participate in osteogenic differentiation through various ways and play a key role.
OBJECTIVE: To discuss the research progress of circRNAs during osteogenic differentiation in human mesenchymal stem cells.
METHODS: Using “circRNAs, human mesenchymal stem cells, osteogenic differentiation” as keywords in English and Chinese. PubMed, Web of Science, CNKI, and Wanfang were searched for relevant articles on circRNAs in human mesenchymal stem cells published from 1993 to 2020. Types of retrieved articles included reviews, research papers, and books.
RESULTS AND CONCLUSION: CircRNAs play an important role in the osteogenesis of mesenchymal stem cells. These circRNAs have proven to be key targets for the diagnosis and treatment of bone diseases. However, the molecular mechanism of circRNA in osteogenic differentiation needs further research, and in vivo experiments are also needed to support existing conclusions.

Key words:stem cell, mesenchymal stem cell, circular RNAs, osteogenic differentiation, tissue engineering, review