|
|
2022, Vol. 26 ›› Issue (1): 112-118Regulation of proliferation, differentiation and apoptosis of bone-related cells by long-stranded non-coding RNAFeng Zhiguo, Sun Haibiao, Han Xiaoqiang
Abstract: BACKGROUND: Long-stranded non-coding RNA is an important epigenetic regulator that controls gene expression and affects a variety of biological processes. More and more evidence shows that long-stranded non-coding RNA plays a potential role in regulating the proliferation, differentiation and apoptosis of bone marrow mesenchymal stem cells, osteoblasts, osteoclasts and chondrocytes. OBJECTIVE: To review the latest research progress on the effects of long-stranded non-coding RNA on the function of bone marrow mesenchymal stem cells, osteoblasts, osteoclasts and chondrocytes, the regulatory mechanism of long-stranded non-coding RNA and the signal pathway involved, in order to provide a new theoretical basis for the treatment of osteoporosis and osteoarthritis. METHODS: PubMed, Biosos Preview and Web Of Science were used to search the related articles published from database inception to August 2020. The retrieval key words were “long non-coding RNA, bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, chondrocytes, differentiation, signal pathway”. Finally, 68 articles related to this article were selected according to inclusion criteria and after screening contents, abstracts, and titles. RESULTS AND CONCLUSION: (1) Long-stranded non-coding RNA is a key regulatory molecule with multiple biological functions. Long-stranded non-coding RNA regulates different signal pathways through various mechanisms, and further regulates the proliferation, differentiation and apoptosis of medullary mesenchymal stem cells, osteoblasts, osteoclasts and chondrocytes, and inhibit or promote the process of osteoporosis and osteoarthritis. (2) Common Long-stranded non-coding RNA regulatory signal pathways include WNT, TGF-β/BMPs, NOTCH and PI3K/AKT. These signaling pathways often have crosstalk, and are jointly involved in the regulation of bone cell metabolism. Coding RNA and non-coding RNA regulate each other by competing for miRNA binding sites. Key words:long-stranded non-coding RNA, bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, chondrocytes, differentiation, signal pathway |