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2022, Vol. 26 ›› Issue (1): 119-124Effect and mechanism of the effective components of Chinese medicine on promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytesLiu Xiaogang, Li Tian, Zhang Duo
Abstract: BACKGROUND: Bone marrow mesenchymal stem cells are one of the most popular seed cells in cartilage tissue engineering. With the continuous advancement of medical research, many experiments have shown that certain active ingredients of traditional Chinese medicine can promote the induction of bone marrow mesenchymal stem cells into chondrocytes. OBJECTIVE: To review the regulatory mechanism and existing problems of different types of compound Chinese medicines and single Chinese medicine and their application in promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytes, in order to provide research ideas for the promoting effect of the effective ingredients of Chinese medicine on the differentiation of bone marrow mesenchymal stem cells into chondrocytes. METHODS: The first author searched the relevant articles in CNKI, Wanfang, PubMed, Scopus and Web of Science databases, and used “compound Chinese medicine; single Chinese medicine; bone marrow mesenchymal stem cell; chondrocytes; tissue engineering” as the Chinese and English search terms. Finally, 60 articles meeting the criteria were selected for review. RESULTS AND CONCLUSION: (1) The active ingredients of certain compound Chinese medicines and single Chinese medicine have a promoting effect on the induction of bone marrow mesenchymal stem cells into chondrocytes, which is an important part of the application of Chinese medicine in cartilage tissue engineering research. (2) Using the effective ingredients of traditional Chinese medicine to induce bone marrow mesenchymal stem cells to differentiate into chondrocytes, and gradually applying them to cartilage tissue engineering for cartilage repair, has become a hot trend in the continuous development and growth of Chinese medicine. Among them, Tougu Xiaotong Granules have good effects with ginsenosides, astragaloside IV, and ligustrazine, and more experimental projects can be launched for research. Key words:stem cells, bone marrow mesenchymal stem cells, chondrocytes, compound Chinese medicine, single Chinese medicine, tissue engineering, review |