2022, Vol. 26 ›› Issue (1): 125-129

Research hotspots and application potential of stem cells from human exfoliated deciduous teeth

Wei Shan1, Li Qin2, Su Yi2   

Abstract: BACKGROUND: The stem cells from human exfoliated deciduous teeth have strong proliferation and differentiation potential and can be easily obtained, and then have gradually become a research hotspot in the field of stem cells.
OBJECTIVE: To review the general biological characteristics and clinical treatments of stem cells from human exfoliated deciduous teeth.
METHODS: Wanfang, CNKI, VIP, Medline, and PubMed databases were searched, with the Chinese subject headings “stem cells from deciduous teeth, micro-environment, gene therapy” and English subject headings “human exfoliated deciduous teeth, dental pulp, stem cell, gene therapy”. A total of 239 articles were obtained by preliminary examination. The latest research articles in the last 5 years and the articles with impact factor over 5 in recent 10 years were selected. The articles were evaluated by all the authors, and 196 articles with repeated content and outdated content and poor correlation were excluded. Finally, 44 articles were included for review.
RESULTS AND CONCLUSION: Stem cells from human exfoliated deciduous teeth have a high proliferation rate and can differentiate into a variety of tissues. Stem cells from human exfoliated deciduous teeth are easy to get, and there is no immune rejection reaction. With the emergence of more and more stem cell banks, stem cells from human exfoliated deciduous teeth will provide broader application prospects for tissue engineering and medicine.

Key words:stem cells, deciduous teeth, dental pulp stem cells, micro-environment, proliferation, differentiation, gene, review