|
|
2022, Vol. 26 ›› Issue (1): 135-140Research status and problems of stem cells and their derived exosomes for prevention and treatment of vascular restenosisShuai Zhiqin1, Chen Jiameng1, Liu Taotao1, Hu Anling1, Li Lisheng1, Yu Limei2, Xu Shangfu1, 2
Abstract: BACKGROUND: Restenosis seriously affects the long-term effect of interventional therapy for coronary atherosclerotic heart disease. The multi-directional differentiation ability and secretion function of stem cells are closely related to the occurrence, development and outcome of restenosis. Stem cells provide new ideas for the prevention and treatment of vascular restenosis, and have great potential advantages. OBJECTIVE: To summarize the effect and mechanism of endothelial progenitor cells, mesenchymal stem cells and stem cell derived exosomes. METHODS: CNKI and PubMed databases were searched with the keywords of “stem cell”, “exosomes” and/or “restenosis” in English and Chinese, separately. Finally, 83 articles were included for review. RESULTS AND CONCLUSION: (1) Restenosis seriously affects the long-term efficacy of coronary intervention, which is still an important issue to be solved in clinical practice. (2) Endothelial progenitor cell and mesenchymal stem cell transplantation can prevent and treat vascular restenosis. The mechanism mainly involves direct differentiation and repair of vascular endothelium and paracrine, and influences the microenvironment of injured vessels. (3) Stem cell derived exosomes can not only produce stem cell transplantation like effects, but also avoid the defects of stem cell transplantation, which has unique potential advantages in the prevention and treatment of vascular restenosis. Key words:stem cells, endothelial progenitor cells, mesenchymal stem cells, exosomes, blood vessels, restenosis, review |