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2022, Vol. 26 ›› Issue (1): 141-147Latest progress and mechanisms of mesenchymal stem cells on premature ovarian failureLi Zhongkang, Zheng Jiahua, Tian Yanpeng, Huang Xianghua
Abstract: BACKGROUND: Premature ovarian failure is a common gynecological endocrine disease, which seriously affects the patient’s physiological, fertility, and psychological functions. Unfortunately, curative therapies are not available at present, and current treatments are mainly address the symptoms. Mesenchymal stem cell transplantation is performed with excellent results and has been widely studied in premature ovarian failure. However, the mechanisms behind it are still undergoing intensive research. OBJECTIVE: To summarize and analyze the research progress of mesenchymal stem cells in the treatment of premature ovarian failure in recent years, to explore the related treatment mechanisms, and to evaluate its potential for clinical treatment so as to provide a theoretical basis for research and clinical application. METHODS: We searched the articles in CNKI and PubMed with the keywords of “mesenchymal stem cells, premature ovarian failure, premature ovarian insufficiency” in Chinese and English, respectively. Finally, 55 articles met the criteria for review. RESULTS AND CONCLUSION: All kinds of mesenchymal stem cells have a great therapeutic effect on premature ovarian failure cell and animal models. The therapeutic mechanisms include homing, promoting cell proliferation, inhibiting cell apoptosis, differentiation, immunoregulation, secreting a variety of cytokines, regulating autophagy and regulating ovarian microenvironment. In addition to a large number of basic researches, related clinical researches have also been carried out. However, its clinical application research is still in its infancy, and its safety and effectiveness still need to be verified by further clinical studies. Key words:premature ovarian failure, mesenchymal stem cells, exosomes, microvesicles, granulosa cells, follicles, therapeutic mechanism, cell proliferation, apoptosis, review |