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2022, Vol. 26 ›› Issue (1): 148-152

Effect and mechanism of mesenchymal stem cells in the treatment of diabetic nephropathy

Wang Shuyun, Xie Junhui, Yu Xuefeng   

  1. Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, Hubei Province, China

  • Received:2020-07-26 Revised:2020-07-28 Accepted:2020-09-26 Online:2022-01-08 Published:2021-10-25

  • Contact: Yu Xuefeng, Professor, Doctoral supervisor, Master’s supervisor, Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, Hubei Province, China Xie Junhui, Associate professor, Associate chief physician, Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, Hubei Province, China

  • About author:Wang Shuyun, MD, Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, Hubei Province, China

  • Supported by:

    the National Natural Science Foundation of China for the Youth, No. 81600634 (to XJH)



Abstract: BACKGROUND: Diabetic nephropathy has become one of the main causes of end-stage renal disease, but clinical treatment is still limited. In recent years, studies have found that mesenchymal stem cells exert renal protective effects in diabetic nephropathy.
OBJECTIVE: To review the research advances of mesenchymal stem cells in diabetic nephropathy from three aspects: the pathogenesis and general treatment strategies of diabetic nephropathy, the characteristics and clinical application of mesenchymal stem cells, and the renal protective effect of mesenchymal stem cells on diabetic nephropathy.
METHODS: Relevant research, reviews and treatises were searched in PubMed database and the search terms included “mesenchymal stem cells, MSCs, diabetic nephropathy, diabetic kidney disease”. Totally 62 articles were included for review based on inclusion and exclusion criteria.

RESULTS AND CONCLUSION: The research of mesenchymal stem cells in disease treatment has been widely carried out. However, there are few clinical trials of mesenchymal stem cells in the treatment of diabetic nephropathy, and the clinical efficacy is limited. Animal experiments have confirmed that mesenchymal stem cells can play a protective role in kidney and delay the progression of diabetic nephropathy. The mechanisms include reducing renal cell apoptosis, regulating autophagy, ameliorating inflammation, suppressing oxidative stress, and inhibiting fibrosis.

Key words:mesenchymal stem cells, diabetic nephropathy, clinical trials, animal experiments, mechanism research


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