Journal Info

Journal Info

副标题

For Authors

For Authors

副标题

For Reviewers

For Reviewers

副标题

2022, Vol. 26 ›› Issue (1): 153-159

Research hotspots and application value of tissue-engineered skin

Lin Miaoyuan1, Li Yuwan2, Liu Yi3, Chen Bei1, Zhang Li1   

  1. 1Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China; 2Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100191, China; 3Department of Joint Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China

  • Received:2021-01-06 Revised:2021-01-08 Accepted:2021-02-05 Online:2022-01-08 Published:2021-10-25

  • Contact: Zhang Li, Professor, Master’s supervisor, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China Li Yuwan, MD, Attending physician, Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100191, China

  • About author:Lin Miaoyuan, Master candidate, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China

  • Supported by:

    Chinese Postdoctoral Science Foundation, No. 2020M680258 (to LYW)



Abstract: BACKGROUND: Tissue-engineered skin has a good application prospect in promoting skin tissue wound repair and scarless healing.
OBJECTIVE: To review the current research progress, application and value of tissue-engineered skin in vivo and in vitro.
METHODS: A computer was used to search the relevant articles in the CNKI database and PubMed database. The Chinese and English search terms were “mesenchymal stem cells; growth factors; skin; wounds; skin repair; wound healing; regenerative medicine; tissue engineering; scaffolds”. The domestic and foreign related application articles on tissue-engineered skin construction in the treatment of skin tissue injury in recent years were checked, and the research progress of mesenchymal stem cells, growth factors, scaffold materials and dressings for new treatment methods for tissue repair was also summarized. The articles irrelevant to the subject of this article were excluded, and 78 articles were finally included for the result analysis.

RESULTS AND CONCLUSION: The construction of tissue-engineered skin involves the selection of seed cells, the application of growth factors, and the combination of multiple elements of scaffold materials. Mesenchymal stem cells are one of the important sources of tissue-engineered skin seed cells. Growth factors optimize the tissue culture environment, and scaffold materials provide appropriate mechanical support. Therefore, how to select appropriate seed cells, growth factors and scaffold materials to construct tissue-engineered skin to treat wounds and speed up repair is the focus and research direction that should be explored in the future. In addition, the development of wound materials is also a new field.

Key words:mesenchymal stem cells, growth factors, skin, wounds, regenerative medicine, tissue engineering, scaffolds, review


分享到:

Publishing Information

Publishing House of Chinese Journal of Tissue Engineering Research


The Official Publication of

Chinese Association of Rehabilitation Medicine

Contact Us

General editorial enquiries:

Email: bwb01@crter.org

Copyright related contact:

Email: crter@crter.org

Commercial Sales contact (Reprints, advertising, etc.):

Email: bwb@crter.org