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2022, Vol. 26 ›› Issue (10): 1582-1587Repair and regenerative therapies of the annulus fibrosusFang Xiaoyang1, Tang Tian2, Wang Nan1, Qian Yuzhang1, Xie Lin2
Abstract: BACKGROUND: When the integrity of the annulus fibrosus is destroyed and the annulus fibrosus breaks, it will aggravate the protrusion of nucleus pulposus, and accelerate the degeneration of intervertebral disc, which finally lead to the occurrence of corresponding diseases. Therefore, restoring the integrity of the annulus is of great significance for the prevention and treatment of diseases. OBJECTIVE: To review the research progress of annulus fibrosus repair and regeneration at home and abroad. METHODS: A comprehensive search was conducted for the studies published until December 2020 with the key words of “annulus fibrosus, repair and regeneration, tissue engineering, gel, cell therapy” in Chinese and “annulus fibrosus, repair and regeneration, tissue engineering, hydrogel, cell” in English on the CNKI, Wanfang and PubMed databases. RESULTS AND CONCLUSION: Some progresses have been made in the mechanics and biology of annulus fibrosus repair and regeneration. At present, it is considered that mechanical repair of annulus fibrosus (annulus fibrosus suture, annulus fibroplasty and radiofrequency thermocoagulation) can only partially repair the outer annulus fibrosus and restore the disordered tissue structure, which is not worthy of further study. Biological methods of repairing and regenerating annulus fibrosus include gel, tissue engineering, biological patch and so on. Compared with mechanical repair, biological treatment can better restore full-thickness annulus fibrosus and restore relatively ordered structure, which is close to the structure and function of natural annulus fibrosus. However, there are still many problems: (1) selection and implantation of materials; (2) phenotype of annulus fibrosus cell is difficult to be confirmed; (3) the stability of long-term biomechanics is unknown; (4) lack of human experiments. Therefore, we can start from the above aspects and combine the cytology, biochemistry, materials science, mechanics and other disciplines to realize the repair and regeneration of damaged annulus fibrosus and its application in clinic as soon as possible. Key words:annulus fibrosus, repair, regeneration, tissue engineering, intervertebral disc, review |