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2022, Vol. 26 ›› Issue (10): 1597-1603Advantages and disadvantages of interbody implant materials in lumbar fusionChen Zhengyu1, 2, Tong Jie3, Li Xuelin1, 2, Yan Yiguo1, 2
Abstract: BACKGROUND: In recent years, with the optimization and improvement of various new interbody implant materials, it has effectively promoted the development of interbody fusion, and the renewal of interbody implant materials provides an important basis for the improvement of interbody fusion. OBJECTIVE: To describe the development, advantages and disadvantages of all kinds of interbody implant materials commonly used at present, so as to provide some references for the selection of suitable interbody fusion materials in clinic. METHODS: Relevant articles in Chinese and English published in PubMed, CNKI, Wanfang and China Biomedical Literature Database from January 1990 to April 2021 were retrieved. Search terms were “Interbody fusion materials, Autogenous bone, Allogeneic bone, Hydroxyapatite, Titanium alloy, Tantalum, Polymer, Carbon fiber, PEEK, BMP2, Lumbar fusion, Lumbar interbody fusion” in English and Chinese, separately. After screening, 66 articles were included and reviewed. RESULTS AND CONCLUSION: (1) At present, there are many kinds of interbody fusion materials used in clinic, which can be divided into autogenous bone, allogeneic bone, hydroxyapatite, titanium alloy/tantalum, polymer, and bone-induced composite materials. Each material has its own characteristics ,advantage, and scope of application. (2) From an objective point of view, autogenous bone transplantation is still the first choice for clinical lumbar interbody fusion, but its biggest deficiency is the limited bone collection and related complications in the bone donor area, which limits its clinical application. However, it also indirectly promotes the sustained development of other intervertebral implant materials. (3) From the perspective of the development of interbody fusion, now more and more researchers further pursue the biomimetic fusion of the spine in order to achieve the reconstruction of physiological anatomy and function. (4) Nowadays, with the in-depth development of material science, tissue engineering, biomechanics and augmentation manufacturing technology, composite intervertebral implant materials or biological composite bone composed of inducing factors are used to replace internal implants. The advantages complement each other in the form of composite, which further improves the rate of interbody fusion and has a good development prospect in the field of spinal fusion. However, long research cycles and large clinical sample size are still needed to explore and prove the real clinical efficacy. Key words:interbody fusion, prostheses and implants, cage, medical material, bone substitutes, 3D printing, review |