2022, Vol. 26 ›› Issue (10): 1610-1614

Application advantages of hydroxyapatite surface modification as a bone scaffold for tissue engineering

Hou Jianfei, Wang Fuke, Yang Guiran, Liao Xinyu, Jia Di, Liu Dejian   

Abstract: BACKGROUND: Due to the large difference in physical and chemical properties between hydroxyapatite and polymer materials, poor interfacial compatibility and easy aggregation, the mechanical and biological properties of the composite materials are poor, which limits the application of hydroxyapatite in tissue engineered bone.
OBJECTIVE: To review the methods of surface modification of hydroxyapatite for the preparation of tissue engineered bone in recent years, and to briefly discuss the reaction mechanism and effect of these methods.
METHODS: On Wanfang, CNKI, VIP, PubMed Central Medine, Google academic databases, articles on the research progress of hydroxyapatite surface modification as tissue engineered bone scaffold were searched using the Chinese search term of “temperature sensitive gel, slow release, drug delivery pathway” and the English search term of “hydroxyapatite, surface modification, tissue engineered bone”.
RESULTS AND CONCLUSION: Up to now, a variety of materials surface modification methods, such as surface active agent, silane coupling agent and grafted polymer, have made some progress, but the effect of a modified method for single is still limited. We can consider putting two or many kinds of modification methods and the modifier in combination to complement each other for a better modification effect. Surface modification is not only to improve the dispersivity of the hydroxyapatite, and increase mechanical properties of the composites, but also will have biological activity, can promote bone regeneration of bioactive factors, such as peptides on the surface of hydroxyapatite, and thus improve the biological properties of composite materials, realize the control on the properties of hydroxyapatite, and the preparation of excellent performance of the tissue engineered bone.

Key words:artificial bone repair materials, tissue engineering, hydroxyapatite, surface modification, tissue engineered bone, review