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2022, Vol. 26 ›› Issue (10): 1620-1624Application of biomaterial and tissue engineering in reconstruction of tympanic membrane defectWen Ke1, Lu Yanqing1, Hou Nan1, Ma Ruina2, Cui Pengcheng2, Lü Die1, Xu Xiaoli1
Abstract: BACKGROUND: The use of tissue engineering technology to repair perforated tympanic membrane can effectively reduce the incidence of postoperative complications. OBJECTIVE: To review the research progress of repairing materials for tympanic membrane perforation. METHODS: The computer was used to retrieve databases, including PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure. English literature published from 2000 to 2020 and Chinese literature published from 2018 to 2020 were retrieved. Key words in English were “tympanic membrane, acute/chronic tympanic membrane perforation, tissue engineering”; key words in Chinese were “tympanic membrane perforation, tissue engineering”. Finally, the clinical feasibility and repair prognosis of each method were summarized. RESULTS AND CONCLUSION: Tympanic membrane perforation can lead to hearing loss and repeated ear abscess, affecting the quality of life to patients seriously. Tissue engineering technology is a trend to repair tympanic membrane perforation, which can also have the function and structure of the original tympanic membrane without the risk of being taken from autologous materials. Tissue engineering of tympanic membrane repair includes three elements: seed cells, scaffold materials (providing mechanical support for cell expansion, migration and differentiation), and bioactive substances (providing suitable microenvironment for tissue growth). Tissue engineering materials can reduce the risk of infection and hematoma caused by acquiring autologous tissues as repairing materials, and can also be selected according to the situation of tympanic membrane perforation, which provides a new research directions and treatment solutions for repairing tympanic membrane. Key words:material, tympanic membrane perforation, tympanic membrane repair, tissue engineering, biomaterial, review |