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2022, Vol. 26 ›› Issue (11): 1752-1757

Osteosarcopenia: muscle-bone interactions

Li Xiaowei1, Deng Chengyuan2, Zhou Guijuan3, Chen Xiaocui3, Liao Ying3   

  1. 1Department of Orthopedics, 3Department of Rehabilitation Medicine, the Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China; 2Hunan Traditional Chinese Medical College, Zhuzhou 412008, Hunan Province, China

  • Received:2021-01-18 Revised:2021-01-20 Accepted:2021-03-27 Online:2022-04-18 Published:2021-12-13

  • Contact: Liao Ying, Chief physician, Master’s supervisor, Department of Rehabilitation Medicine, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China

  • About author:Li Xiaowei, Master candidate, Department of Orthopedics, the Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China

  • Supported by:

    School-level Major Special Project of University of South China, No. USCKF201902K02 (to LY)



Abstract: BACKGROUND: Studies have found that there is a reduction in the quality of life of patients with osteosarcopenia and an increase in the risk of hospitalization. Compared to patients with osteoporosis or sarcopenia alone, patients with osteosarcopenia have a higher risk of falls and fractures. However, there are few epidemiological reports on osteosarcopenia, with the relationship between bones and muscles being unknown, and few treatment measures have developed.
OBJECTIVE: To elucidate the interaction between bone and muscle and the prevention and treatment of osteosarcopenia, thereby calling for an early intervention system.
METHODS: PubMed and CNKI were searched for relevant articles published from 1996 to 2020 using the keywords of “osteosarcopenia, epidemiology, interaction between skeleton and muscle, intervention, treatment.” A total of 424 articles were initially examined, and 74 articles were finally included for analysis and summary after screening and sorting.

RESULTS AND CONCLUSION: Bone and muscle have similar tissue origin and are differentiated from each other under in vivo or in vitro factors. The adjacent anatomical relationship provides the basic conditions for mechanical signals and chemical signals. The interaction between bone and muscle is mainly realized through mechanical stimulation and its secreted bioactive factors. Like most diseases, the prevention of osteosarcopenia is more important than its treatment. Bone and muscle mass peaks at a young age and then begins to decline with age. The complex and multifactorial characteristics of osteosarcopenia require multifaceted prevention and treatment strategies. The main prevention and treatment measures include: resistance training, nutrition diet therapy, drug therapy, etc. Currently, no enough attention has been paid to osteosarcopenia in China. Therefore, establishing the corresponding early intervention system in China is lagging behind or even a gap in relevant fields.

Key words:osteosarcopenia, epidemiology, interaction between skeleton and muscle, intervention, treatment


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