2022, Vol. 26 ›› Issue (11): 1765-1771

Regulatory role and mechanism of non-coding RNA on steroid-induced osteonecrosis of the femoral head

Huang Yangjun, Zhou Honghai, Chen Longhao, Li Jilin, Lu Qingwang, Li Dongyang, He Xinyu   

Abstract: BACKGROUND: Steroid-induced osteonecrosis of the femoral head is difficult to be detected in the early stage, and the pathogenesis is not clear. Therefore, steroid-induced osteonecrosis of the femoral head is liable to be ignored and misses the best treatment time, resulting in a high disability rate in the late stage. Studies have shown that non-coding RNA is associated with the development of steroid-induced osteonecrosis of the femoral head.

OBJECTIVE: To summarize the relevant literature worldwide and to review the regulatory mechanism of non-coding RNA expression on the pathogenesis of steroid-induced osteonecrosis of the femoral head, so as to further understand its pathogenesis.
METHODS: A search of PubMed, Web of Science, CNKI, WanFang, and VIP was performed for articles related to non-coding RNA and steroid-induced osteonecrosis of the femoral head. The keywords were “miRNA, lncRNA, circRNA, glucocorticoids, steroid, dexamethasone, osteonecrosis of the femoral head, bone marrow mesenchymal stem cells” in English and Chinese, respectively. Reproductive studies and non-reference literatures were excluded, and 48 eligible articles were finally included.
RESULTS AND CONCLUSION: Non-coding RNA is involved in the pathogenesis of steroid-induced osteonecrosis of the femoral head by regulating the differentiation of bone marrow mesenchymal stem cells, osteocyte metabolism, vascular endothelial cell formation and lipid metabolism. Non-coding RNA is expected to be a biomarker for the clinical diagnosis and prognosis of steroid-induced osteonecrosis of the femoral head. Interference with abnormally expressed non-coding RNAs or miRNAs of exosomal origin may become a new strategy for the clinical treatment of steroid-induced osteonecrosis of the femoral head in the future.

Key words:bone, necrosis of the femoral head, steroid, non-coding RNA, miRNA, LncRNA, circRNA, review