|
|
2022, Vol. 26 ›› Issue (11): 1799-1804Role and mechanism of tetramethylpyrazine in spinal cord injury repairJiang Shengyuan, Deng Bowen, Xu Lin, Liu Gang, He Feng, Zhao Yi, Ren Jingpei, Mu Xiaohong
Abstract: BACKGROUND: Tetramethylpyrazine has a wide range of pharmacological effects, such as improving microcirculation, anti-inflammatory, inhibiting apoptosis and other functions, which has a significant effect in repairing spinal cord injury. OBJECTIVE: To review the mechanism of tetramethylpyrazine in the repair of spinal cord injury in order to provide references for the research and treatment of spinal cord injury. METHODS: A computer-based online search of China National Knowledge Infrastructure database and PubMed was performed for relevant articles published from 2003 to 2020, using the keywords of “tetramethylpyrazine, spinal cord injury, ischemia-reperfusion injury” in Chinese and English, respectively. Finally, 85 articles were included for further review. RESULTS AND CONCLUSION: The mechanism of tetramethylpyrazine in spinal cord injury repair has not yet been fully elucidated in animal experiments. The main mechanisms of tetramethylpyrazine in the treatment of spinal cord injury include inhibition of endothelin generation, inhibition of vascular endothelial cell apoptosis, antagonism of calcium ion influx, regulation of interleukin, inhibition of nuclear factor-кB signaling pathway, inhibition of neutrophil infiltration and inhibition of nerve cell apoptosis. There are few reports on the clinical use of tetramethylpyrazine monomer injection to treat spinal cord injury, and its clinical efficacy remains to be further explored. Key words:tetramethylpyrazine, spinal cord injury, ischemia-reperfusion injury, angiogenesis, apoptosis, inflammatory response, review |