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2022, Vol. 26 ›› Issue (12): 1931-1936

Advantages of micro CT in three-dimensional reconstruction of specimens and its application in animal models of osteoarthritis

Du Longlong1, Yuan Puwei1, Yang Wei2, Li Xuefeng1, Gao Qimeng1   

  1. 1Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China; 2Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China

  • Received:2021-06-26 Revised:2021-07-08 Accepted:2021-09-04 Online:2022-04-28 Published:2021-12-15

  • Contact: Yuan Puwei, MD, Professor, Chief physician, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China

  • About author:Du Longlong, Master candidate, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China

  • Supported by:

    the Li’s Orthopedic Inheritance Studio Construction Project of Chang’an Medicine, No. [2018] 40 (to YPW); Shaanxi Provincial Key Laboratory of Bone Degenerative Disease Prevention and Treatment of Integrated Traditional Chinese and Western Medicine Construction Project, No. [2018] 32 (to YPW); Xianyang Key Laboratory Construction Project, No. 2019k01-53 (to YPW)



Abstract: BACKGROUND: There are many factors in the pathological process of osteoarthritis, including synovial inflammation, cartilage loss, subchondral bone damage, bone hyperplasia and so on. The specific mechanism is not yet clear. Micro CT is a non-destructive imaging tool, which can form high-resolution 3D images of samples, and realize the research of related structures and functions of bone and cartilage, quantitative evaluation of disease progression and treatment, and contrast-enhanced soft tissue imaging. Micro CT scanning of osteoarthritis animal model can clarify the pathological changes of joints, articular cartilage, subchondral bone, synovium, blood vessels and other tissues in the course of osteoarthritis, which is conducive to the study of the pathological progress of osteoarthritis.
OBJECTIVE: To summarize the imaging methods and research prospects of micro CT in joints, cartilage, subchondral bone, synovium and intraosseous vessels of osteoarthritis animal model, so as to provide a new method for the study of the pathological mechanism of osteoarthritis.
METHODS: By searching the databases of CNKI, Web of Science, Embase, PubMed and Wanfang, the Chinese and English keywords were “osteoarthritis, micro CT, pathology”. The qualified articles with strong correlation and relatively new publication years were selected for review.

RESULTS AND CONCLUSION: (1) Micro CT has good imaging performance in joints, cartilage, subchondral bone, and intraosseous vessels. The imaging method is mature, which changes the shortcomings of traditional pathological sections on destroying tissue integrity and cumbersome steps. (2) Micro CT has not been reported in the literature on the imaging of synovium, but it has a good performance in the imaging of soft tissues, such as fat and tumor. The imaging of synovium has a research prospect in the future. (3) Micro CT can carry out three-dimensional reconstruction of specimens, break through the limitations of conventional two-dimensional pathological sections, and provide a new model for the study of the pathological mechanism of osteoarthritis.

Key words:osteoarthritis, micro CT, animal model, pathology, cartilage, subchondral bone, intraosseous blood vessel, review


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Chinese Association of Rehabilitation Medicine

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