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2022, Vol. 26 ›› Issue (12): 1950-1955Role of TRPV5 and TRPV6 calcium channels in bone metabolismLi Chao1, Zhang Xian2, Shao Jiahao1
Abstract: BACKGROUND: Transient receptor potential (TRP) channels constitute a large and diverse family of cationic channels, which act as cellular sensors to respond to a large number of physical and chemical stimuli in and out of the body. Calcium is an important part of bone tissue, and calcium-related regulatory factors can play a role in bone formation and resorption through changes in Ca2+ concentration. The bone metabolism in the development of osteoporosis is to a large extent the metabolism process of calcium ions, and TRPV5/6 is an important channel of trans-cellular calcium ion transport. The TRP family is highly permeable to Ca2+, so there is a close relationship between epithelial calcium channels and bone metabolism. OBJECTIVE: To review the relationship between bone metabolism and calcium, the characteristics and physiological functions of Ca2+ channels TRPV5/6, and the relationship between Ca2+ channels TRPV5/6 and bone metabolism in the process of osteoporosis, which will provide more sufficient evidence for the research on the specific mechanism of anti-osteoporosis in Chinese medicine. METHODS: The first author searched PubMed, CNKI, and WanFang databases for the literatures related to calcium channel TRPV5/6 and bone metabolism published from January 2000 to April 2021 using the keywords of “calcium channel, TRPV5, TRPV6, bone metabolism, traditional Chinese medicine” in English and Chinese, respectively. Finally, 58 articles were retained for review. RESULTS AND CONCLUSION: (1)The balance of osteoclasts and osteoblasts plays an important role in normal bone metabolism. The highly expressed calcium channels TRPV5/6 in human epithelial tissue play a very important role in calcium metabolism throughout the body. (2)The Ca2+ channels TRPV5/6 were highly selective and permeable to Ca2+, and played an effect on bone metabolism after phosphorylation, glycosylation, ubiquitination and other translational modifications. They then exert an effect on osteoclasts or osteoblasts, thereby inhibiting osteoclasts, increasing calcium absorption, and promoting osteogenic effects. (3)The anti-osteoporosis effect of traditional Chinese medicine may be to further improve the activity of TRPV5/6 by increasing the expression of TRPV5/6 in the intestines or kidneys in vivo or increasing the opening amount of TRPV5/6 channels, so as to inhibit the bone resorption of osteoclasts and promote the bone formation of osteoblasts, eventually preventing and treating osteoporosis. Key words:TRP ion channel, bone metabolism, osteoporosis, TRPV5, TRPV6, progress |