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2022, Vol. 26 ›› Issue (13): 2062-2068Effect and mechanism of astrocytes in spinal cord injuryLi Shuai, Fan Yiming, Liu Fangyu, Zhang Hongyu, Wang Yansong
Abstract: BACKGROUND: Clinical manifestations of spinal cord injury are related to the severity and location of injury. Although the research on spinal cord injury has lasted for many years, there is still no effective treatment to restore the function of injured spinal cord. OBJECTIVE: To review the characteristics of astrocytes, the activation of reactive astrocytes in recent years and the related therapeutic strategies. METHODS: In PubMed database, the key words of “spinal cord injury, astrocyte” were searched. The key words of “spinal cord injury, astrocyte” were searched in Wanfang and CNKI. The retrieval time limit was from January 2010 to October 2020. According to the inclusion and exclusion criteria, articles unrelated to the research purpose, long-standing and repetitive articles were excluded, and 61 articles meeting the criteria were included for review. RESULTS AND CONCLUSION: The physiological functions of astrocytes are diverse and are very important for maintaining the stability of the central nervous system. Astrocytes can also be activated into reactive astrocytes after spinal cord injury, which will have beneficial or adverse effects on the nervous system. Treatment of spinal cord injury with astrocytes can effectively improve neurological function, reduce inflammatory reaction after spinal cord injury, and promote axon growth and remyelination. The activation types and mechanisms of reactive astrocytes need to be further explored, and the safety and cost issues of related treatment strategies need to be further solved. Therefore, it is necessary to explore the mechanism of astrocytes in spinal cord injury. Key words:spinal cord injury, secondary spinal cord injury, astrocyte, reactive astrocyte, nerve regeneration, review |