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2022, Vol. 26 ›› Issue (13): 2075-2080Effects of various methods on improving bone marrow mesenchymal stem cell transplantation for spinal cord injurySun Jianwei1, Yang Xinming2, An Xiaogang3
Abstract: BACKGROUND: Bone marrow mesenchymal stem cells are adult pluripotent stem cells with strong proliferation and multi-differentiation potential without ethics and rejection. They have been proven effective in a large number of spinal cord injury-related experiments and become the most promising seed cells for treatment of spinal cord injury. OBJECTIVE: To summarize the latest research progress of various treatment methods to promote bone marrow mesenchymal stem cell transplantation for spinal cord injury. METHODS: Related articles were retrieved in CNKI, Wanfang and PubMed databases from January 1999 to October 2020, with the search terms of “bone marrow mesenchymal stem cells, cell transplantation, spinal cord injury” in Chinese and English. Basic and clinical studies of bone marrow mesenchymal stem cell transplantation for spinal cord injury were screened, and repetitive studies were excluded. A total of 66 articles were included in the study. RESULTS AND CONCLUSION: (1) Bone marrow mesenchymal stem cell transplantation combined with other treatments can significantly improve the therapeutic effect of spinal cord injury, among which the combination of biological tissue engineering or related drugs is an important research direction in the treatment of spinal cord injury in the future. (2) Bone marrow mesenchymal stem cell transplantation has great potential in the clinical treatment of spinal cord injury. Key words:stem cells, bone marrow mesenchymal stem cells, cell transplantation, spinal cord injury, nerve repair, culture, review |