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2022, Vol. 26 ›› Issue (13): 2081-2086Effect and mechanism of traditional Chinese medicine regulating mesenchymal stem cell-derived exocrine for ischemic strokeChen Na, Fan Feiyan, Li Shuangli, Zhang Yunke
Abstract:BACKGROUND: Exosome is a membranous vesicle structure, which can be secreted by many types of cells and widely exists in blood, urine, cerebrospinal fluid, breast milk and other body fluids. It has the potential to mediate cell-to-cell communication and activate a variety of signal pathways. Studies have shown that mesenchymal stem cell-derived exocrine bodies can not only directly affect the function of brain parenchyma cells, but also have indirect neural repair effect, as a drug loading system can improve the therapeutic effect of traditional Chinese medicine. OBJECTIVE: To review the research progress on the mechanism of mesenchymal stem cell-derived exocrine bodies regulated by traditional Chinese medicine in the treatment of ischemic stroke. METHODS: The articles of Wanfang, CNKI, PubMed, Web of Science and other databases about mesenchymal stem cell-derived exocrine bodies regulated by traditional Chinese medicine in the treatment of ischemic stroke from 2009 to 2020 were searched, with “mesenchymal stem cells, exocrine, traditional Chinese medicine, ischemic stroke” as the key words in Chinese and English. The outdated and repetitive viewpoints were excluded, and the retrieved articles were analyzed and sorted out, and a total of 66 articles were included for analysis. RESULTS AND CONCLUSION: (1) The biological characteristics of exocrine derived from mesenchymal stem cells were combed. (2) Summarizing the mechanism of mesenchymal stem cell-derived exocrine in the treatment of ischemic stroke, including affecting blood-brain barrier permeability, angiogenesis, neurodifferentiation, nerve repair and immune inflammation. (3) Through the existing research, this paper summarizes the role of traditional Chinese medicine in regulating mesenchymal stem cell-derived exocrine in the treatment of ischemic stroke, including neuroprotection, angiogenesis, regulation of blood-brain barrier and so on. It may provide relevant reference for the clinical application of traditional Chinese medicine to regulate mesenchymal stem cell-derived exocrine in the treatment of ischemic stroke in the future. Key words:mesenchymal stem cells, exocrine, traditional Chinese medicine, ischemic stroke, neuroprotection, angiogenesis, blood-brain barrier, review |