Journal Info

Journal Info

副标题

For Authors

For Authors

副标题

For Reviewers

For Reviewers

副标题

2022, Vol. 26 ›› Issue (13): 2087-2092

Action mechanism of traditional Chinese medicine on regulating ischemia-hypoxia microenvironment and delaying stem cell senescence based on ciRs-7/miR-7 signaling pathway

Wang Shiqi1, Hui Xiaoshan2, An Lanhua1, Yuan Shuzhang1, Zhang Jinsheng3   

  1. 1Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China; 2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; 3Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, Henan Province, China

  • Received:2021-01-07 Revised:2021-01-08 Accepted:2021-02-10 Online:2022-05-08 Published:2021-12-20

  • Contact: Zhang Jinsheng, Chief physician, MD, Professor, Doctoral supervisor, Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, Henan Province, China

  • About author:Wang Shiqi, Doctoral candidate, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China Hui Xiaoshan, Doctoral candidate, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Wang Shiqi and Hui Xiaoshan contributed equally to this article.

  • Supported by:

    the National Natural Science Foundation of China, No. 81673893 (to ZJS)



Abstract: BACKGROUND: Stem cell senescence is a part of the body’s aging. Regulating the ischemia-hypoxia microenvironment through extracellular signaling pathways may be an important method to delay stem cell aging.
OBJECTIVE: To explore the mechanisms and methods of delaying stem cell senescence based on the relationship between extracellular signaling pathway and ischemia-hypoxia microenvironment in recent years.
METHODS: Using the keywords of “ciRs-7/miR-7, stem cell, ischemia-hypoxia microenvironment, aging” in Chinese and English, we searched Chinese Journal Full-Text Database, PubMed and Wanfang Database for articles about the effects of ciRs-7/miR-7 signaling pathway and ischemia-hypoxia microenvironment on stem cell senescence from 1978 to 2021. Finally, 56 articles were reviewed.  

RESULTS AND CONCLUSION: The level of proliferation, differentiation and autophagy of stem cells decreased and the senescence process of stem cells accelerated under the ischemia-hypoxia microenvironment. Stem cell aging is an important cause of body aging. Delaying stem cell aging by regulating extracellular signaling pathway ciRs-7/miR-7 may become a new method of anti-aging.

Key words:stem cells, senescence, ciRs-7, miR-7, ischemia, hypoxia, review


分享到:

Publishing Information

Publishing House of Chinese Journal of Tissue Engineering Research


The Official Publication of

Chinese Association of Rehabilitation Medicine

Contact Us

General editorial enquiries:

Email: bwb01@crter.org

Copyright related contact:

Email: crter@crter.org

Commercial Sales contact (Reprints, advertising, etc.):

Email: bwb@crter.org