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2022, Vol. 26 ›› Issue (13): 2087-2092Action mechanism of traditional Chinese medicine on regulating ischemia-hypoxia microenvironment and delaying stem cell senescence based on ciRs-7/miR-7 signaling pathwayWang Shiqi1, Hui Xiaoshan2, An Lanhua1, Yuan Shuzhang1, Zhang Jinsheng3
Abstract: BACKGROUND: Stem cell senescence is a part of the body’s aging. Regulating the ischemia-hypoxia microenvironment through extracellular signaling pathways may be an important method to delay stem cell aging. OBJECTIVE: To explore the mechanisms and methods of delaying stem cell senescence based on the relationship between extracellular signaling pathway and ischemia-hypoxia microenvironment in recent years. METHODS: Using the keywords of “ciRs-7/miR-7, stem cell, ischemia-hypoxia microenvironment, aging” in Chinese and English, we searched Chinese Journal Full-Text Database, PubMed and Wanfang Database for articles about the effects of ciRs-7/miR-7 signaling pathway and ischemia-hypoxia microenvironment on stem cell senescence from 1978 to 2021. Finally, 56 articles were reviewed. RESULTS AND CONCLUSION: The level of proliferation, differentiation and autophagy of stem cells decreased and the senescence process of stem cells accelerated under the ischemia-hypoxia microenvironment. Stem cell aging is an important cause of body aging. Delaying stem cell aging by regulating extracellular signaling pathway ciRs-7/miR-7 may become a new method of anti-aging. Key words:stem cells, senescence, ciRs-7, miR-7, ischemia, hypoxia, review |