2022, Vol. 26 ›› Issue (13): 2087-2092
Action mechanism of traditional Chinese medicine on regulating ischemia-hypoxia microenvironment and delaying stem cell senescence based on ciRs-7/miR-7 signaling pathway
Stem cell senescence is a part of the body’s aging. Regulating the ischemia-hypoxia microenvironment through extracellular signaling pathways may be an important method to delay stem cell aging.
To explore the mechanisms and methods of delaying stem cell senescence based on the relationship between extracellular signaling pathway and ischemia-hypoxia microenvironment in recent years.
Using the keywords of “ciRs-7/miR-7, stem cell, ischemia-hypoxia microenvironment, aging” in Chinese and English, we searched Chinese Journal Full-Text Database, PubMed and Wanfang Database for articles about the effects of ciRs-7/miR-7 signaling pathway and ischemia-hypoxia microenvironment on stem cell senescence from 1978 to 2021. Finally, 56 articles were reviewed.
The level of proliferation, differentiation and autophagy of stem cells decreased and the senescence process of stem cells accelerated under the ischemia-hypoxia microenvironment. Stem cell aging is an important cause of body aging. Delaying stem cell aging by regulating extracellular signaling pathway ciRs-7/miR-7 may become a new method of anti-aging.
stem cells, senescence, ciRs-7, miR-7, ischemia, hypoxia, review