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2022, Vol. 26 ›› Issue (13): 2093-2098Function and hot spot of adipose-derived stem cell exosomes in tissue regeneration and repairLi Jianyi, Liu Zhiyuan, Deng Chengliang
Abstract: BACKGROUND: Adipose-derived stem cells have become one of the popular seed cells in regenerative medicine due to abundant content and easy harvest. Adipose-derived stem cell exosomes are served as a bridge and link among adipose-derived stem cells and other cells and have the effects on regulating immune and inflammatory responses, promoting self-repair of damaged cells, and are considered as an alternative treatment for adipose-derived stem cells. OBJECTIVE: To review research progress and challenges in the adipose-derived stem cell exosomes regulating tissue regeneration. METHODS: CNKI, Wanfang database and PubMed, and Web of Science database were searched for related articles with the search terms of “adipose-derived stem cells; adipose stem cells; exosomes” in English and Chinese. After preliminary screening of articles based on inclusion and exclusion criteria, 70 articles with high relevance and reference value were retained for review. RESULTS AND CONCLUSION: Adipose-derived stem cell exosomes have shown the therapeutic potential in various diseases, such as skin wounds, neurodegenerative diseases, tumors, bone regeneration, kidney diseases, cardiovascular diseases, immune diseases, and fibrotic disease. Key words:stem cell, adipose-derived stem cells, exosomes, alternative treatment, clinical application, tissue regeneration, review |