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2022, Vol. 26 ›› Issue (13): 2114-2119Role and mechanism of cell therapy in repair of peripheral nerve injuryGong Chao1, Zhang Yuqiang1, 2, 3, Wang Wei1, 2, 3
Abstract: BACKGROUND: Cell therapy is a promising branch of medical tissue engineering and regenerative medicine, and which is a good strategy for the repair of peripheral nerve injury. OBJECTIVE: To review the common repair methods of peripheral nerve injury, several cells commonly used for peripheral nerve injury repair and the mechanism of cell therapy to promote peripheral nerve injury repair. METHODS: The key words were “cell therapy, stem cell therapy, peripheral nerve injury, repair” in English and Chinese. Wanfang, CNKI and PubMed databases were retrieved for the articles concerning the cell therapy in the repair of peripheral nerve injury published from 2010 to 2020. After excluding repetitive, old and irrelevant articles, 45 eligible articles were further analyzed. RESULTS AND CONCLUSION: (1) After summarizing the common repair methods of peripheral nerve injury, such as conventional direct suture, nerve graft, and nerve transfer, and the advantages and disadvantages of each method were described. (2) Several kinds of cells commonly used for peripheral nerve injury repair, such as Schwann cells, olfactory ensheathing cells, and embryonic stem cells, were reviewed, and the defects of various cells were pointed out. (3) The mechanism of cell therapy to promote peripheral nerve injury repair was summarized, which was mainly manifested in the application of Schwann cells or Schwann cells-like cells, secretion of neurotrophic factors, extracellular matrix molecules and cell adhesion molecule, and promotion of myelin formation. Key words:cell therapy, stem cell therapy, peripheral nerve injury, repair, regeneration, role, mechanism, review |