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2022, Vol. 26 ›› Issue (14): 2279-2284

Effects of SOX9 on chondrocyte differentiation

Yang Shuang, Yan Jinglong   

  1. Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China

  • Received:2021-01-26 Revised:2021-01-28 Accepted:2021-03-27 Online:2022-05-18 Published:2021-12-22

  • Contact: Yan Jinglong, Chief physician, Doctoral supervisor, Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China

  • About author:Yang Shuang, Master candidate, Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China


Abstract: BACKGROUND: Chondrocytes are the source of seed cells for cartilage repair engineering. Chondrocyte differentiation is closely related to endochondral ossification, which is an essential for bone development. SOX9 plays an important role in the regulation of chondrocytes.
OBJECTIVE: To review the latest research progress in the regulatory mechanism of SOX9 on chondrocyte differentiation at different levels.
METHODS: A computer search was conducted for the relevant literatures published in CNKI, WanFang, and PubMed until December 2020. The key words were “cartilage, chondrocyte, regulation of SOX9 gene expression, posttranscriptional regulation, protein processing, posttranslational modification, functional partner” in Chinese and “cartilage, chondrocyte, posttranscriptional regulation, posttranslational modification, SOX9, transcriptional regulation, gene expression regulation, SOX9 transcription factor“ in English, respectively. Finally, 61 eligible articles were included for further review.

RESULTS AND CONCLUSION: The key mechanisms involved in SOX9 regulation at the gene, RNA, and protein levels have been discovered. The SOX9 key factors can directly or indirectly promote osteogenic growth of chondrocytes, either positively or negatively, or even due to the interaction between various factors. SOX9 is a key factor in chondrocyte differentiation and chondrogenesis. By systematically analyzing the molecular mechanism of SOX9 regulation at different levels, the theoretical basis for cartilage tissue engineering can be provided, to accelerate the clinical treatment and application in cartilage diseases.

Key words:cartilage, chondrocytes, SOX9, gene expression regulation, transcription, cell differentiation, mRNA, osteoarthritis


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