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2022, Vol. 26 ›› Issue (15): 2400-2405

Angiogenesis regulation in bone repair: new ideas and new methods

Peng Huizhen1, 2, 3, Cai Mingxiang3, 2, 1, Liu Xiangning1, 2, 3   

  1. 1College of Stomatology, Jinan University, Guangzhou 510632, Guangdong Province, China; 2Clinical Research Platform for Interdiscipline of Stomatology, Jinan University, Guangzhou 510630, Guangdong Province, China; 3First Affiliated Hospital of Jinan University & Department of Stomatology, Guangzhou 510630, Guangdong Province, China

  • Received:2021-09-14 Revised:2021-10-15 Accepted:2021-11-23 Online:2022-05-28 Published:2022-01-06

  • Contact: Liu Xiangning, PhD, Chief physician, Associate professor, College of Stomatology, Jinan University, Guangzhou 510632, Guangdong Province, China; Clinical Research Platform for Interdiscipline of Stomatology, Jinan University, Guangzhou 510630, Guangdong Province, China; First Affiliated Hospital of Jinan University & Department of Stomatology, Guangzhou 510630, Guangdong Province, China

  • About author:Peng Huizhen, Master candidate, College of Stomatology, Jinan University, Guangzhou 510632, Guangdong Province, China; Clinical Research Platform for Interdiscipline of Stomatology, Jinan University, Guangzhou 510630, Guangdong Province, China; First Affiliated Hospital of Jinan University & Department of Stomatology, Guangzhou 510630, Guangdong Province, China

  • Supported by:

    Natural Science Foundation of Guangdong Province, No. 2021A1515010882 (to LXN); Guangzhou Science and Technology Plan Project, No. 202102010040 (to LXN)


Abstract: BACKGROUND: Angiogenesis is a key component of bone reconstruction. Promoting bone vascularization thereby can accelerate bone repair. There are numerous research methods for promoting angiogenesis, and significant progress has been made in the field of bone defect repair in recent years.  
OBJECTIVE: To review several cutting-edge methods and developments in promoting angiogenesis and repairing bone defects in recent years, as well as their applications in bone tissue engineering.
METHODS: The first author used the Chinese search terms “angiogenesis, osteogenesis, bone defect, tissue engineering, exosomes” and English search terms “angiogenesis, osteogenesis, bone defect, exosomes, vascularization” to find relevant publications in CNKI, WanFang, PubMed, and Web of Science databases. After screening and excluding articles irrelevant to the research purpose and repetitive articles, 69 articles were finally selected for review.  
RESULTS AND CONCLUSION: At present, promising results have been achieved in the bone defect remodeling research. Bone vascularization can be promoted by growth factors, delivery genes, biologically active ions, small molecule active peptides, and Chinese medicine monomers. Each has its own advantages and challenges, and faces different challenges. The synthesis of small molecule active peptides has low cost, high efficiency and safety, with obvious advantages. It has the potential to generate new ideas and methods for vascularization in bone tissue engineering.
Key words: angiogenesis, osteogenesis, bone defect, tissue engineering, exosome, review

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Chinese Association of Rehabilitation Medicine

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