2022, Vol. 26 ›› Issue (16): 2492-2497

Influence of lay-down angles on mechanical properties of three-dimensional printed polycaprolactone scaffolds

Liu Jiali1, Suo Hairui1, 2, Yang Han1, Wang Ling1, 2, Xu Mingen1, 2

1College of Automation, Hangzhou Dianzi University, Hangzhou 310018, Zhejiang Province, China; 2Zhejiang Provincial Key Lab of Medical Information and Three-Dimensional Bio-Printing, Hangzhou 310018, Zhejiang Province, China

Received:2020-12-01 Revised:2020-12-05 Accepted:2021-01-23 Online:2022-06-08 Published:2021-10-29
Contact: Xu Mingen, Professor, College of Automation, Hangzhou Dianzi University, Hangzhou 310018, Zhejiang Province, China; Zhejiang Provincial Key Lab of Medical Information and Three-Dimensional Bio-Printing, Hangzhou 310018, Zhejiang Province, China
About author:Liu Jiali, Master candidate, College of Automation, Hangzhou Dianzi University, Hangzhou 310018, Zhejiang Province, China
Supported by:
the National Natural Science Foundation of China, No. 61675059 (to WL); the National Key Research & Development Program of China, No. 2017YFC1103400 (to XME)

Abstract: BACKGROUND: Three-dimensional (3D) printed polycaprolactone scaffold is one of the hotspots in recent years. It is difficult to prepare porous scaffolds with appropriate materials and excellent mechanical properties in current studies.
OBJECTIVE: To manufacture 3D porous polycaprolactone scaffolds with different lay-down angles and study their mechanical properties.

METHODS: 3D porous polycaprolactone scaffolds with different lay-down angles (0°/90°, 0°/60°, 0°/60°/120°, 0°/45° and 0°/45°/90°/135°) were designed and prepared using 3D printer. The porosity, compression and tensile properties of the scaffold were measured.

RESULTS AND CONCLUSION: (1) There was no significant difference in the porosity of the five scaffolds (P > 0.05). (2) In Z direction compression, there was little difference for polycaprolactone scaffolds with different lay-down angles. (3) In Y direction, the compression of the 0°/45°, 0°/60°, and 0°/90° scaffolds increased with the increase of the filling angle. The compressive modulus and strength of 0°/45°/90°/135° were higher than those of 0°/45°. The compressive modulus and strength of 0°/60°/120° scaffolds were stronger than those of 0°/60°. (4) When the three scaffolds were compressed in X direction, the law of the compression modulus and strength of the scaffold was opposite to those of the compression in the Y direction. Among the five types of scaffolds, the tensile modulus and strength of the 0°/45°/90°/135° scaffolds were the largest, and the tensile modulus and strength of the 0°/90° scaffold were the smallest; the tensile strength and modulus of the 0°/45°, 0°/60°, and 0°/90° scaffolds decreased with the increase of the angle. (5) The results show that the 0°/90° and 0°/60°/120° scaffolds can meet the requirements of the physiological environment with isotropic mechanical properties, and the other three structures can meet the requirements of the anisotropic growth environment of human tissues.

Key words:3D printing, tissue engineering, polycaprolactone, scaffold, lay-down angles, anisotropic, mechanical properties, tensile, compression

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