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2022, Vol. 26 ›› Issue (16): 2576-2583Effects of biochemical modification of titanium implant surface on the osseointegrationChe Zhenjia, Zhu Zhengqing, Zhu Liwei, Li Youbin, Zhu Chenyi, Huang Lanfeng
Abstract: BACKGROUND: Titanium and titanium alloys are widely used in the field of orthopedic implantation, because of their good mechanical properties and biological inertia. OBJECTIVE: To review the effects of different biomolecules on titanium implant surface on osseointegration. METHODS: PubMed, Web of Science, VIP, Wanfang, and CNKI were searched using “titanium, osseointegration, biochemical modification, coating” as keywords in Chinese and English for relevant articles published from 1991 to 2020. Finally, 104 articles were included in result analysis after screening and summarizing. RESULTS AND CONCLUSION: The single physical and chemical modification of titanium surface is mainly affecting the cell behavior indirectly, and the biomolecular coatings can be directly involved in the biological process, which is more effective in bone formation, not only greatly improves the early osseointegration between bone and the implants, but also reduces the incidence of surgical failure and prosthesis revision due to inflammatory reaction. Although the biochemical modification of titanium implants can be directly involved in the biological process, there are still plenty of problems that need to be solved: the long-term stability, releasing rate, and mechanism between the implants and cells and tissues need to be further studied to achieve early and long-term osseointegration between bone and the implants. Key words:titanium, implants, osseointegration, surface modification, biochemical modification, coating, biomolecule, osteogenic differentiation |