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2022, Vol. 26 ›› Issue (16): 2596-2601Topical simvastatin administration in the treatment of periodontitis: effect of loading on sustained drug release system or biomaterial scaffold systemLiu Xiaolin1, 2, Liu Shutai1, Han Xiaoqian2, Mu Xinyue3
Abstract: BACKGROUND: Traditional periodontal therapy cannot restore periodontal soft and hard tissue. It is hoped to explore the effect of local simvastatin administration system on periodontitis, and open up a new way for clinical treatment of periodontitis. OBJECTIVE: To review the mechanisms of simvastatin on promoting periodontal bone regeneration and on treating periodontitis, as well as the advantages, disadvantages and preparation methods of local simvastatin drug delivery system, biomaterial scaffold system and local gel drug delivery system. METHODS: The first author retrieved the articles published from 1988 to 2020 in PubMed, Wanfang, CNKI and other literature databases. The English key words were “simvastatin; microspheres; hydrogels; periodontitis; bone tissue engineering”. The Chinese key words were “simvastatin; sustained drug release; biomaterial scaffold; gel system; periodontitis; bone tissue engineering”. A total of 50 articles that met the criteria were included for review. RESULTS AND CONCLUSION: With the development of tissue engineering, experimental and clinical studies have mixed growth factors, scaffold materials and carriers to prepare copolymer with more biocompatibility, fluidity and promotion of bone regeneration, which is used to assist the treatment of periodontitis and has achieved good results. In recent years of research, some scholars loaded simvastatin on sustained release system; some scholars loaded simvastatin on biomaterial stent system; some scholars loaded simvastatin on the gel drug delivery system. All these methods have good slow-release drug effect, and promote the periodontal bone regeneration. Key words: simvastatin, slow release of drugs, biomaterial scaffolds, gel system, periodontitis, bone tissue engineering |