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2022, Vol. 26 ›› Issue (16): 2613-2617Long-circulating lipsomes: application and mechanismCai Xiaoxuan1, 2, Lü Yingnian1, 3, Qi Yi2, 3
Abstract: BACKGROUND: At present, liposomes have been used as drug carriers, in which long-circulating liposomes can further improve the bioavailability of drugs. OBJECTIVE: To summarize the research status and development trend of long-circulating liposomes at home and abroad from the aspects of classification, application fields and action mechanism. METHODS: Wanfang, CNKI, PubMed and Web of Science were searched by entering keywords “liposomes long-circulating, hypertension, peptides” in Chinese and “PEG, antihypertensive, long-circulating liposomes, diabetes, tumour, virus, peptide” in English. Through reading the title and abstract for preliminary screening, the articles with low relevance to the topic were excluded. Finally, 57 articles were included for the result analysis. RESULTS AND CONCLUSION: (1) Long-circulating liposomes are not easily absorbed by mononuclear phagocyte system and can prolong the circulation time of drugs in vivo, so they play an important role in anti-hypertension, anti-tumor, anti-diabetes, anti-virus and other diseases. (2) Significant progress has been made in the development of various materials for surface modification of liposomes, such as polyethylene glycol. (3) The latest preparation methods of liposomes, such as microfluidic technology, supercritical fluid method and ethanol injection method, make up for the shortcomings of traditional preparation methods. Key words:long-circulating liposomes, liposomes, polyethylene glycol, action mechanism, application, review |