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2022, Vol. 26 ›› Issue (19): 3048-3055Implications of preclinical research on mesenchymal stem cells: relationship between cell function of mesenchymal stem cells and the JAK/STAT signaling pathwayZou Wanghui1, Qian Nannan1, Zhang Meng1, Pang Qiming2, Yang Yichun3, Zhang Tao1
Abstract: BACKGROUND: Mesenchymal stem cells are a kind of pluripotent stem cells that have powerful functions in promoting tissue repair and immune regulation, and have become an important source of seed cells in the field of regenerative medicine. JAK/STAT signaling pathway, as a signaling pathway shared by many cytokines, can have a wide range of effects on the functions of mesenchymal stem cells themselves and their target cells. OBJECTIVE: To briefly describe the research progress of the relationship between JAK/STAT signaling pathway and mesenchymal stem cell function, provide an important reference for understanding the signaling pathway mechanism of mesenchymal stem cell function changes, and provide a theoretical reference for related mesenchymal stem cell preclinical research. METHODS: We searched relevant articles published from 2001 to 2021 in Wanfang database, CNKI, and PubMed. The key words were “mesenchymal stem cell, JAK/STAT, cell differentiation, immunomodulation” in Chinese and English. Finally, 48 articles were included for analysis. RESULTS AND CONCLUSION: Mesenchymal stem cells can affect the JAK/STAT signaling pathway of target cells through extracellular secretion, and produce the effect of reversing the imbalanced microenvironment. In addition, the osteogenic differentiation, immunomodulation, adaptive changes, and homing effects of mesenchymal stem cells are all related to the JAK/STAT signaling pathway. (1) In terms of osteogenic differentiation, after cytokines activate JAK/STAT signaling pathway, mesenchymal stem cells can differentiate into osteoblasts. (2) In terms of immune regulation, JAK/STAT signaling pathway regulates mesenchymal stem cells, to express corresponding surface antigens or release cytokines, and promotes the proliferation of specific types of immune cells. (3) In terms of adaptive changes, JAK/STAT signaling pathway regulates mesenchymal stem cells in the in vivo or in vivo culture environment to have a high survival rate. (4) In terms of homing, the JAK/STAT signaling pathway regulates the migration of mesenchymal stem cells along the direction of target cells of chemokines. Key words:mesenchymal stem cells, JAK/STAT signaling pathway, cell signaling pathway, cell function, immunomodulation, tissue differentiation, homing, review |