|
|
2022, Vol. 26 ›› Issue (19): 3071-3077Application of mesenchymal stem cells and exosomes in liver regenerationBai Jiameng1, Liu Guangwei2, Xie Lu1, Mao Yaoyao1, He Huichang1, Wang Chunjing1
Abstract: BACKGROUND: Many studies have shown that mesenchymal stem cells have broad application prospects in the field of regenerative medicine. In addition to mesenchymal stem cells themselves, exosomes derived from mesenchymal stem cells have also become the focus of researchers’ attention, which brings new ideas for the treatment of diseases. OBJECTIVE: To review the application, challenge and prospect of mesenchymal stem cells and their exosomes in the field of liver regeneration, and to further understand their therapeutic mechanism. METHODS: With the search terms of “mesenchymal stem cells, MSCs, exosomes, liver, regenerate”, relevant articles published in PubMed database, Wanfang database and CNKI database were searched. Through screening and sorting, the articles unrelated to the research content, repetitive studies and early published articles were excluded. Finally, 85 articles were reserved for review. RESULTS AND CONCLUSION: Mesenchymal stem cells and their exosomes can play a protective role in the liver and delay the progress of the disease. The specific mechanisms include reducing hepatocyte apoptosis, regulating autophagy, improving inflammatory response, improving oxidative stress, inhibiting fibrosis, and promoting angiogenesis, which can be used as a new direction for the treatment of liver injury related diseases. Key words: stem cells, mesenchymal stem cells, exosomes, liver regeneration, mechanism, review |