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2022, Vol. 26 ›› Issue (19): 3078-3083Effect and mechanism of mesenchymal stem cell-related long non-coding RNA on cell proliferation and apoptosisQiu Hanke, Zhang Fei, Peng Wuxun
Abstract: BACKGROUND: Mesenchymal stem cells have been widely used in the field of medical regeneration, and how to improve their therapeutic effect is the current research focus. Long-chain non-coding RNA is involved in the occurrence and development of many diseases. Some studies have shown that mesenchymal stem cell-related long-chain non-coding RNA is involved in the regulation of cell proliferation and apoptosis, but its specific role and mechanism are not completely clear. Understanding its role and mechanism may provide new strategies to improve the application effect of mesenchymal stem cells. OBJECTIVE: To review the role and mechanism of mesenchymal stem cell-related long-chain non-coding RNA in cell proliferation and apoptosis. METHODS: CNKI and PubMed were retrieved using “mesenchymal stem cells, long non-coding RNA, proliferation, apoptosis” as Chinese and English search words. After excluding outdated and repetitive views, the retrieved articles were sorted out, and 74 articles were selected for review. RESULTS AND CONCLUSION: (1) Long non-coding RNA is involved in regulating the proliferation and apoptosis of mesenchymal stem cells. (2) Long non-coding RNA associated with mesenchymal stem cells can regulate the proliferation and apoptosis of host cells. (3) The main mechanisms of long non-coding RNA are as follows: competitive endogenous RNA as micro-RNA, directly affecting key transcription factors, and enhancing related signal pathways. (4) The long non-coding RNA associated with mesenchymal stem cells may be a new strategy to improve the application effect of mesenchymal stem cells. Key words:stem cells, mesenchymal stem cells, long non-coding RNA, proliferation, apoptosis, review |