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2022, Vol. 26 ›› Issue (19): 3090-3094Mechanism of mesenchymal stem cell transplantation in the treatment of osteoporosisTang Zhihong, Duan Hao, Zhong Zongyu, Wang Weizhou, Chen Yongcheng, Li Xiaozhuang, Wang Yanghao, Liu Zhui, He Fei
Abstract: BACKGROUND: For the treatment of osteopenia, cell therapy is a hot spot in current research. How to select seed cells and understand its treatment mechanism will help promote the clinical application of mesenchymal stem cells. OBJECTIVE: To summarize the research progress of mesenchymal stem cells in the treatment of osteoporosis in recent 10 years. METHODS: With “osteoporosis, mesenchymal stem cells” as Chinese and English keywords, CNKI, Wanfang database and PubMed database were searched respectively. The search time was set from January 2010 to January 2021, and 158 related articles were initially found. After reading and analyzing, 63 articles were selected for summary. RESULTS AND CONCLUSION: Mesenchymal stem cells from different sources can produce therapeutic effects on different types of osteoporosis. However, its therapeutic effect is affected by homing efficiency, and its therapeutic mechanism involves many aspects, such as osteogenesis and angiogenesis. This makes mesenchymal stem cells have great advantages over traditional drugs in the treatment of osteoporosis. However, the adverse effects of teratogenicity and tumorigenesis and the ethical issues involved are still the main factors hindering its clinical application. Key words:stem cells, mesenchymal stem cells, osteoporosis, exosomes, homing, review |