2022, Vol. 26 ›› Issue (19): 3095-3099

Prospects and clinical transformation value on the application of dental follicle stem cells in the regeneration and repair of teeth and periodontal tissue

Meng Shengzi, Liu Rong, Luo Yaxin, Bi Haoran, Chen Xiaoxu, Yang Kun

Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China

Received:2021-03-10 Revised:2021-04-15 Accepted:2021-07-22 Online:2022-07-08 Published:2021-12-29
Contact: Yang Kun, MD, Associate professor, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
About author:Meng Shengzi, Master candidate, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Supported by:
the National Natural Science Foundation of China, No. 81760199 (to YK); the National Natural Science Foundation of China, No. 81860196 (to YK); the Science and Technology Fund of Guizhou Province, No. [2020]1Y328 (to YK)

Abstract: BACKGROUND: As a kind of dental mesenchymal stem cells, dental follicle stem cells have considerable application prospect and clinical transformation value in stem cell therapy and tissue engineering because of their excellent characteristics.
OBJECTIVE: To review the basic characteristics of dental follicle stem cells and their latest progress in the field of regeneration and repair of tooth and periodontal complex tissue structure.
METHODS: The key words were “dental follicle stem cell, regeneration, tooth, bone, periodontal tissue, tissue engineering, review” in Chinese and English. PubMed, Sciencedirect, Medline, CBM, CNKI, and other databases were retrieved in articles published from 2010 to 2021. Finally, 61 articles were included for analysis and discussion.

RESULTS AND CONCLUSION: As dental mesenchymal stem cells, dental follicle stem cells have great application value in the field of oral regenerative medicine, and they have the characteristics of rich sources, multi-directional differentiation, and low immunogenicity. At present, dental follicle stem cells are actively used in the regeneration of periodontal tissue, tissue engineering biological root reconstruction and alveolar bone repair. Their therapeutic potential in other tissue injuries and immune system diseases has been continuously explored in recent years. However, before more in-depth clinical application, how to better regulate the functional mechanism of transplanted dental follicle stem cells and control the immune system response, in order to further optimize the construction methods of teeth and periodontal tissue, is worthy of in-depth research and discussion.

Key words: stem cells, dental follicle stem cell, regeneration, repair, tooth, bone, periodontal tissue, tissue engineering, review

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