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2022, Vol. 26 ›› Issue (2): 283-288Expression and role of cannabinoid receptors during bone remodelingFan Danyang1, Fu Runze1, Mi Jiajing1, Liu Chunyan2
Abstract: BACKGROUND: How cannabinoid receptors regulate the role of osteoblasts and osteoclasts and maintain the normal process of bone remodeling is of great significance for the normal development of bone, the maintenance of bone mass and the treatment of osteoporosis and periodontitis. OBJECTIVE: To review the relationship between cannabinoid receptor and bone remodeling and its related factors, so as to provide ideas for the treatment of osteoporosis, periodontitis and other clinical applications. METHODS: We searched relevant articles published from July 2001 to July 2020 in PubMed, FMRS, CNKI, WanFang databases with the keywords of “endocannabinoid systems, the endocannabinoid receptors, osteoblasts, osteoclasts, bone mass, bone remodeling, oral health, osteoporosis, periodontitis” in Chinese and English, respectively. Finally, 77 articles met the criteria for review. RESULTS AND CONCLUSION: Bone remodeling depends on the interaction between osteoblasts and osteoclasts. The imbalance between bone resorption and bone formation will affect the process of bone remodeling and lead to bone inflammatory diseases such as osteoporosis and periodontitis. The endogenous cannabinoid system contains a variety of receptors, all of which belong to the G protein coupling superfamily. The two main receptors (cannabinoid type I and cannabinoid type II) are expressed in osteoblasts, osteoclasts and bone marrow mesenchymal stem cells and other bone-related cells. Under the action of natural ligands or synthetic agonists, cannabinoid receptors can produce specific physiological effects in vivo and in vitro through different metabolic pathways, thus regulating the generation and differentiation of osteocytes, and eventally affecting bone mass and bone metabolism. Further research on the mechanism of bone formation and bone loss has been a focus of current research, to provide new treatment ideas for the clinical work of bone-related diseases. Key words:cannabinoid receptor, osteoblast, osteoclast, bone marrow mesenchymal stem cells, bone mass, bone remodeling, osteoporosis, periodontitis |