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2022, Vol. 26 ›› Issue (2): 302-307Predictive value of blood biomarkers for brain injury after cardiac arrestLiu Xiaopeng1, Zhang Sisen1, 2, 3
Abstract: BACKGROUND: Neurological prognostication is crucial after cardiac arrest. To some extent, the blood biomarkers can help predict the neurological prognostication of brain injury after cardiac arrest. OBJECTIVE: To review the current advances in blood biomarkers of brain injury after cardiac arrest. METHODS: PubMed, CNKI, VIP and WanFang were searched for literatures related to the use of blood biomarkers for predicting brain injury after cardiac arrest. Keywords were “cardiac arrest, biomarkers, brain injury” in English and Chinese, respectively. RESULTS AND CONCLUSION: In recent years, various biomarkers have played an increasingly important role in the neurological prognostication of brain injury after cardiac arrest. Although many promising results have been achieved in new biomarkers, the thresholds for predicting poor outcomes of biomarkers vary greatly in different studies, indicating that no standardization requirements of these methods have been achieved. None of the measures assessed can predict adverse neurological outcomes with absolute certainty, and the multi-model approach still seems to be the most prudent prediction strategy. None of the evaluated indicators can be definitely absolute to predict adverse neurological outcomes, and the multi-modal approach still seems to be a prediction strategy that is most cautious. Conventional brain injury markers, such as neuron specific enolase and S100B, still have important advantages. Currently, further explorations on new blood biomarkers are warranted, and new breakthroughs can be achieved by more accurate outcome predictions in this field. Key words:cardiac arrest, biomarker, brain injury, prognosis, review |