2022, Vol. 26 ›› Issue (22): 3580-3585

Application of polycaprolactone modified biological barrier membrane in bone tissue engineering

Lu Haiping1, Lang Xuemei2, Zhang Cheng1, Ju Songli1, Zhang Yi3, Wang Xin1   

Abstract: BACKGROUND: The use of polycaprolactone barrier membrane can prevent the surrounding fast-growing fibrous tissue and epithelial tissue from entering the bone defect thus enhancing bone regeneration process. In addition, the osteogenic modification of the polycaprolactone barrier membrane has been explored by researchers.
OBJECTIVE: To summarize the modification strategies of polycaprolactone barrier membrane, and look forward to new osteogenesis strategies.
METHODS: CNKI, Wanfang, VIP, and PubMed databases were searched with key words of “polycaprolactone membrane, osteogenesis, bone substitute material, natural polymer, artificial polymer, metal ion, growth factor, stem cell” in both Chinese and English for articles regarding polycaprolactone barrier membrane published from January 2000 to February 2021.   
RESULTS AND CONCLUSION: The first problem to be solved for polycaprolactone is to reduce the hydrophobicity when combining with other materials. At present, many methods have been developed as connecting bridges to make polycaprolactone more compatible with other materials, such as dopamine, heparin, and collagen. However, the combination of polycaprolactone with different materials requires diverse conditions, and new hydrophobicity modification methods still need to be explored. In addition, polycaprolactone material and its modification strategies have been widely studied. The research of the incorporation of polycaprolactone with bone substitute material, natural polymer and artificial polymer has achieved pleasing results. Nevertheless, due to the limitation of osteogenesis of composite materials, new osteogenic materials still need to be developed. Presently, there are some substances (such as exosomes and extracellular matrix) that have been verified to exhibit superior osteogenic ability for many kinds of tissues, such as peripheral nerve regeneration and vascular regeneration. The incorporation of polycaprolactone with those active substances is expected to develop into new regeneration strategies for tissue engineering.
Key words: polycaprolactone, barrier membrane, osteogenesis, bone regeneration, bone tissue engineering, composite materials, review