2022, Vol. 26 ›› Issue (22): 3602-3608

Angiogenesis induced by bone bioscaffold materials

Li Duchenhui, Tian Ai, Tang Zhenglong   

Abstract: BACKGROUND: The vascular network induced by the bioscaffold material is essential for cell survival and new bone formation. In recent years, scholars of bone tissue engineering have paid more attention to the influence of different scaffold materials on angiogenesis during bone regeneration.
OBJECTIVE: To describe the characteristics of bone scaffold materials that can promote angiogenesis and their role in promoting vascularization.
METHODS: The first author used “osteogenesis, biomaterials, bone defect, angiogenesis, vascularization” as the English search terms, and used “osteogenic differentiation, biomaterials, bone defect, angiogenesis, vascularization” as the Chinese search terms to search relevant articles published from 2016 to 2020 in the PubMed and CNKI databases. After screening and summarizing, the authors finally chose 82 relevant articles for review.
RESULTS AND CONCLUSION: The early establishment of the vascular network after the implantation of scaffold materials can provide sufficient nutrients and transport metabolites, while the slow formation of local vascular network that leads to insufficient blood supply will delay osteogenesis or even fail to form new bones. Researchers modified the scaffold materials by various methods, such as the change of the physical and chemical properties of the implanted scaffold materials, the loaded sustained-release system with growth factor, and the combination of trace elements or simulation of periosteal structure, to promote early angiogenesis in the process of osteogenesis. However, due to limitations of the current manufacturing technology and the lack of relevant basic research, studies about bioscaffold materials focused on the change of a single factor. In the future, with the improvement of manufacturing technology, the research and development of more new biomaterials will produce bioscaffold materials that integrate porous, micro-nano and multi-level surface morphologies. Meanwhile, with the precise study of the secretion and release of various growth factors during osteogenesis, as well as the precise grasp of the slow-release and controlled-release systems, the angiogenesis-promoting effect of bioscaffold materials will be further improved.
Key words: bone defect, scaffold, biomaterials, angiogenesis, vascularization, bone regeneration, tissue engineering