|
2022, Vol. 26 ›› Issue (23): 3683-3690Screening and biological function analysis of inflammation-related circRNAs in synovial tissue of patients with primary knee osteoarthritisQiao Linghui1, Yuan Tao1, Han Jie2, Wang Guancheng1, Gu Yanglin1
Abstract: BACKGROUND: Primary knee osteoarthritis is one of the most common chronic diseases among the elderly, which brings a heavy burden on society and families. Current clinical treatments only focus on surgeries such as total knee replacement, but it is difficult to prevent cartilage tissue degeneration at an early stage. The formation mechanism of knee osteoarthritis, especially the influence of inflammation in disease progression, has been reported to some extent, but its specific mechanism is still unclear. |