2022, Vol. 26 ›› Issue (25): 4046-4051

Effect and mechanism of human amniotic epithelial cells on nerve injury repair

Wang Kang1, Zhi Xiaodong1, 2, Wang Wei1, 2, 3   

Abstract: BACKGROUND: Compared with other kinds of stem cells, human amniotic epithelial cells are more primitive in development and stronger in expansion. In particular, they have many advantages, such as wide sources, low acquisition costs and strong controllability. They have an important positive effect on the process of nerve damage repair, which is a kind of “seed cell” with wide application prospects.
OBJECTIVE: To summarize the application effect of human amniotic membrane epithelial cells in the treatment of nerve injury, and provide reference and basis for the treatment of clinical nerve injury.
METHODS: Articles in PubMed database from 2000 to 2020 were searched using the search terms of “central nervous system injury, peripheral nerve injury, amniotic epithelial cells, cell therapy, tissue engineering, genetic engineering, repair, regenerate”. Articles in databases of CNKI, VIP and Wanfang from 2000 to 2020 were retrieved with the search terms of “central nervous system injury, peripheral nerve injury, human amniotic epithelial cells, cell therapy, tissue engineering, genetic engineering, repair, regenerate”. The literature and references were reviewed one by one.
RESULTS AND CONCLUSION: Human amniotic epithelial cells have strong nerve tissue repair, regeneration and protection capabilities, which can avoid immune rejection and tumorigenic risks that occur during other stem cell transplantation. They are one of the reliable cell sources for the treatment of neurological diseases. Future research is not only needed to deepen its basic biological characteristics, but also needs to be further developed in differentiation ability.
Key words: human amniotic epithelial cells, central nervous system injury, peripheral nerve injury, cell therapy, tissue engineering, genetic engineering, repair, regenerate, review