2022, Vol. 26 ›› Issue (25): 4058-4063

Mesenchymal stem cells promote wound healing by regulating the autophagy

Zhang Gaofei, Wang Di, Li Jiamei, Lou Hanxiao, Zeng Yueqin, Liu Wenjun   

Abstract: BACKGROUND: In recent years, the role of mesenchymal stem cells in wound healing has received widespread attention. Although mesenchymal stem cells can promote wound healing, its mechanism of action is not completely clear.
OBJECTIVE: To review the role and mechanism of mesenchymal stem cells in promoting wound healing in recent years.
METHODS: Using “mesenchymal stem cells, wound healing, autophagy, stem cells” as Chinese and English key words, related articles were searched on PubMed, Cochrane Library, CNKI, VIP, Wanfang Medical Network, China Biomedical Literature Database from the establishment of the database to March 2021.
RESULTS AND CONCLUSION: Mesenchymal stem cells can promote wound healing by regulating autophagy and wound environment. At the same time, as a new method to promote wound healing, mesenchymal stem cells can be used as an ideal autophagy inducer to promote wound healing, promote the proliferation and migration of wound fibroblasts, inhibit inflammatory reaction, and promote the angiogenesis of endothelial cells, so as to promote the healing of injured wounds. However, the mechanism and promotion of mesenchymal stem cells on autophagy are still unclear. Therefore, the research of autophagy elimination and related molecular mechanism caused by mesenchymal stem cell implantation into wound has become the focus of current wound healing research.
Key words: autophagy, mesenchymal stem cells, wound, wound healing, review, stem cells, fibroblasts, blood vessel