|
2022, Vol. 26 ›› Issue (27): 4346-4352Comparison of the effects between two routes of total flavones of Rhizoma Drynariae administration on large segmental bone defects in rats based on bone tissue engineering techniqueShen Zhen1, Guo Ying1, Jiang Ziwei2, Zhang Yan2, Li Zige2, Chen Zehua3, Ye Xiangling3, Chen Guoqian3
Abstract: BACKGROUND: Composite scaffold has been proven to be effective in treating large segmental bone defects. However, slow bone repair and poor osteogenesis remain to be the main problem. Total flavones of Rhizoma Drynariae can promote osteogenesis and accelerate bone healing, but the route of administration is still confined to intragastric administration and the research about local drug delivery into bone defects is still relatively insufficient. |