DNA hydrogel based on drug delivery and bone tissue engineering
Gao Zhao1, Zhao Yuhao1, He Yixiang1, Zhao Haiyan2, Wang Wenji2
1First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China; 2Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Contact:Wang Wenji, Professor, Chief physician, Master’s supervisor, Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
About author:Gao Zhao, Master candidate, First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China
Supported by:
Fund Project of Lanzhou Talent Innovation and Entrepreneurship Project, No. 2020-RC-45 (to ZHY)
Abstract: BACKGROUND: DNA hydrogel has been widely studied because of its many excellent properties, and it provides a good platform for the development of drug delivery and bone tissue engineering, as well as new research and development ideas. OBJECTIVE: To review several special types of DNA hydrogels, drug delivery based on DNA hydrogels, and the current development and future prospects of bone tissue engineering. METHODS: A computer-based online search of PubMed, Web of Science, Medline, CNKI and Wanfang databases was performed to retrieve articles regarding DNA Hydrogel based on drug delivery and bone tissue engineering published between January and April 2021 with the search terms of “DNA hydrogel, drug delivery, bone defect, osteogenic differentiation, osteogenic factor”. The types of DNA hydrogels and their applications in drug delivery and bone tissue engineering were retrieved. RESULTS AND CONCLUSION: (1) DNA hydrogel is a hydrophilic polymer network composed of cross-linked DNA chains. As a new type of biological material, it is easy to synthesize and modify sequence programmability, hydrophilicity, stimulus response, biocompatibility, biodegradability, molecular recognition and binding, high entrapment efficiency and so on. (2) At present, the preparation methods of purified and hybrid DNA hydrogels are diversified, which can achieve the targeted delivery of general drugs. Immunotherapy can be achieved through the design of DNA structures such as unmethylated cytosine-phosphate-guanine dinucleotides. (3) As a good carrier of antisense single-stranded nucleotides, DNA hydrogel can be used in gene therapy. (4) In the field of bone tissue engineering, DNA hydrogel can be used as a three-dimensional cell culture site for cell culture. It can promote bone formation and bone tissue vascularization by carrying bone marrow mesenchymal stem cells and osteogenic promoting factor. Key words: bone; bone defect; DNA hydrogel; drug delivery; gene therapy; cell culture; osteogenic differentiation; osteogenic factor; target
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Publishing Information
Publishing House of Chinese Journal of
Tissue Engineering Research
