2022, Vol. 26 ›› Issue (27): 4423-4428

Application of drug delivery system in the field of periodontal tissue regeneration

Zhu Meiying, Jiang Liming, Liu Shuangwei, Ma Mingqi, Yang Yutong   

Abstract: BACKGROUND: Local application of growth factors is one of the methods of periodontal tissue regeneration treatment. However, its topical application is limited due to the short half-life of growth factors and their easy dilution and hydrolysis. The drug delivery system can control the release of growth factors so that it can perform biological functions more effectively.  
OBJECTIVE: To summarize the concept, classification and application of drug delivery system in periodontal tissue regeneration treatment.
METHODS: PubMed, CNKI, Wanfang, and VIP databases were searched with the key words of “carrier, drug delivery system, periodontal tissue regeneration, fibers, films, strips, hydrogel, liposome, polymer micelle, microsphere” in English and Chinese, separately. The final 71 articles were included for the review after screening and summarizing in the original 240 articles.
RESULTS AND CONCLUSION: The drug delivery system can control the release of growth factors, protect biological activity of growth factors and then promote the repair and regeneration of damaged tissues.   Drug delivery systems can be classified into fibers, films, strips, hydrogel, and microparticulate/nanoparticulate drug delivery system according to the different forms. With the development of pharmacy, polymer material science and periodontology, materials with biocompatibility and biodegradability are gradually used in the research and production of periodontal growth factor sustained-release preparations. That may provide new directions for clinical treatment, but considering the safety of carrier materials, the operability of preparation methods, and the universality of clinical applications, many drug delivery systems used in the field of periodontal regeneration still need to be improved.
Key words: carrier, drug delivery system, periodontal tissue regeneration, fibers, films, strips, hydrogel, liposome, polymer micelle, microsphere