2022, Vol. 26 ›› Issue (28): 4525-4531

Role and application of polylactic acid-hydroxyacetic acid copolymer scaffolds in bone defect repair and regeneration

Lu Renpei, Zou Zhichen, Zhao Fengnian, Zheng Changming, Song Keguan   

Abstract: BACKGROUND: Polylactic acid-hydroxyacetic acid copolymer with good biocompatibility, plasticity, and full biodegradation becomes the ideal material of artificial bone source. However, its lack of hydrophilic, absence of osteogenesis ability, and acidification environment induced by degradation products are detrimental to bone defect repair. Thus, modification is very necessary.
OBJECTIVE: To review the research progress of polylactic acid-hydroxyacetic acid copolymer scaffolds.
METHODS: The computer was used for article retrieval on CNKI and PubMed databases published from January 2000 to November 2020. The keywords were “polylactic acid-hydroxyacetic acid copolymer, PLGA, bone defect, composite scaffold, hydroxyapatite, tricalcium phosphate, modification, surface modification, blending modification” in English and Chinese, respectively. Articles with low correlation, outdated or repeated articles were excluded.
RESULTS AND CONCLUSION: There are many modification methods of polylactic acid-glycolic acid copolymer scaffold, and the main modification methods are blending modification and surface modification. Blending modification can improve the mechanical properties and hydrophilicity of the scaffold by adding other substances, such as hydroxyapatite, tricalcium phosphate, magnesium hydroxide and other inorganic substances during the scaffold manufacturing, change the cell behavior, and promote osteogenesis. Surface modification is to coat the surface of the scaffold with a layer of active substances to regulate the cell-scaffold interaction. Although the performance of stents has been improved by various methods, there are still many difficulties in clinical application.
Key words: polylactic acid-glycolic acid copolymer, bone defect, composite support, tissue engineering, bone repair materials, bone regeneration, surface modification, blending modification