Application and role of human platelet lysate in tissue repair and regeneration
Xie Xingqin1, Nie Yuqi2, Zhang Yi1
1National and Local Joint Research and Engineering Center for Aging Diseases, Tian Qing Stem Cell Co., Ltd., Harbin 150028, Heilongjiang Province, China; 2Collabera Inc, NJ 07920, USA
Abstract: BACKGROUND: Human platelet lysate, rich in ingredients of tissue healing, is a class of biomaterials for tissue repair and regeneration.
OBJECTIVE: To summarize the composition and preparation of platelet lysate and its recent advances in clinical studies and application in human tissue repair.
METHODS: The first author searched PubMed, clinicaltrials.gov, Chinese Clinical Trial Registry, VIP, Wanfang and CNKI databases for relevant articles and clinical trials published from January 2013 to March 2021. The key words were “human platelet lysate, clinical, trial, regeneration, tissue repair, wound healing, biomaterial” in English and Chinese, separately.
RESULTS AND CONCLUSION: Human platelet lysate can be prepared from autologous/allogeneic peripheral blood or umbilical cord blood and contains a variety of components that facilitate cell growth and wound healing. Current clinical studies have demonstrated the safety and efficacy of human platelet lysate, alone or in combination with cell therapy, in tissue repair. Totally 22 ongoing clinical trials in clinicaltrials.gov involve the treatment of several new indications, including post-COVID-19 acute respiratory distress syndrome, peripheral arterial disease, diabetic foot ulcer, facial aesthetics, and so on. In future, the efficacy of these clinical studies will further increase the role of human platelet lysate in tissue regeneration and repair. The combination of human platelet lysate with tissue engineering materials will lay the foundation for its regenerative repair in large tissue defects.
Key words: human platelet lysate, regeneration, tissue repair, wound healing, biomaterial, clinical, clinical trial