2022, Vol. 26 ›› Issue (29): 4729-4734

Mechanism and application of sterol regulatory element binding protein in wound healing

Zhu Boheng, Peng Ying, Wang Hong   

Abstract: BACKGROUND: Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a series of enzymes required for the synthesis of endogenous cholesterol, fatty acids, phospholipids, and triglycerides. Recent studies have shown that SREBPs can regulate wound healing through the involvement in wound inflammation, angiogenesis, and epidermal cell formation.
OBJECTIVE: To summarize the main mechanism and application of SREBPs in wound repair.   
METHODS: English databases, including PubMed, Web of Science, and Cochrane Library, and Chinese databases, including CNKI, VIP, WanFang, and China Biomedical Literature Database, were searched for relevant literature published from database inception to August 31, 2021. The search terms were “sterol regulatory element binding proteins, wound, inflammation, angiogenesis, epidermis” in Chinese and English.   According to the inclusion and exclusion criteria, 48 documents were included for result analysis.   
RESULTS AND CONCLUSION: SREBP transcription factors can promote wound healing by regulating inflammation, promoting angiogenesis, and reepithelialization. In this review, we list some methods to regulate the activity of SREBP transcription factors. SREBP can regulate human lipid homeostasis, inflammatory responses, angiogenesis, and reepithelialization during wound repair, providing a new research direction for wound repair. To date, there are few clinical trials on the application of SREBP in wound repair, and the specific safety and efficacy of SREBP cannot be fully guaranteed.   
Key words: SREBP, inflammatory response, angiogenesis, reepithelialization, wound repair, review