2022, Vol. 26 ›› Issue (30): 4889-4895

Epimedium in regulating bone marrow mesenchymal stem cell differentiation and preventing osteoporosis related signaling pathways

Huang Wei1, Dong Panfeng1, Huang Yourong1, Xia Tian2

1Department of Orthopedics and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China; 2College of Orthopedics and Traumatology, Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China

Received:2021-11-04 Accepted:2021-12-01 Online:2022-10-28 Published:2022-03-29
Contact: Xia Tian, Doctoral candidate, Associate professor, College of Orthopedics and Traumatology, Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
About author:Huang Wei, Master candidate, Department of Orthopedics and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Supported by:
National Natural Science Foundation of China, No. 81760796, 81960803; Natural Science Foundation for the Youth of Guangxi Zhuang Autonomous Region, No. 2020GXNSFBA159053; Young Teachers' Basic Ability Improvement Project of Guangxi Universities, No. 2019KY0352; Wei Guikang National Medical Master Team Capacity Building, No. {2018} 1; National Famous and Old Traditional Chinese Medicine Inheritance Studio Construction Project in 2016, No. {2016} 11

Abstract: BACKGROUND: With the aging of society, the incidence rate of osteoporosis in many countries is increasing year by year. At present, the cause of osteoporosis is not clear and there is no effective cure for the disease.
OBJECTIVE: To summarize the relevant literature at home and abroad, and sum up the research on the signaling pathway related to the regulation of bone marrow mesenchymal stem cell differentiation by Epimedium, in order to further understand the pathogenesis of osteoporosis and improve new ideas for the treatment of osteoporosis.
METHODS: CNKI, Wanfang, and VIP databases were searched with the Chinese search terms “Epimedium; osteogenic differentiation; bone marrow mesenchymal stem cells; osteoporosis; signal pathway; Wnt/β-catenin; BMP/Runx2/Osz; MAPK”. MEDLINE and PubMed databases were retrieved with the English search terms “Epimedium; osteogenic differentiation; bone marrow mesochemical stem cells; osteoporosis; signal path; Wnt/β-catenin; BMP/Runx2/Osz; MAPK”. To screen the research articles related to Epimedium in regulating bone marrow mesenchymal stem cell differentiation in the treatment of osteoporosis, a total of 61 articles were included according to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: (1) Epimedium and bone marrow mesenchymal stem cells play an important role in the occurrence of osteoporosis. (2) Most studies have found that Epimedium plays a role in the treatment of osteoporosis mainly through signaling pathways such as Wnt/β-catenin, Notch, BMP/Runx2/Osz and MAPK to regulate bone marrow mesenchymal stem cells, so as to affect the dynamic balance between osteoclasts and osteoblasts and achieve the best state of maintaining bone homeostasis. Therefore, in-depth study of Epimedium on bone marrow mesenchymal stem cells in the future may improve the potential value of treating osteoporosis.
Key words: Epimedium, osteogenic differentiation, bone marrow mesenchymal stem cells, osteoporosis, signaling pathway, BMP/Runx2/Osz, MAPK, view

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