2022, Vol. 26 ›› Issue (32): 5201-5208

Hypothalamus: the key controller for exercise-improved bone metabolism

Lu Pengcheng, Liu Bo, Jin Shengjie, Tian Zhikai, Zeng Xinyu, Chen Xianghe   

Abstract: BACKGROUND: Bone metabolism has always been a hotspot in bone tissue engineering research. With the deepening of the mechanism, it has been found that hypothalamus is the main regulatory center for exercise to improve bone metabolism.
OBJECTIVE: To review the role of hypothalamus in bone metabolism and to explore the mechanism of exercise-mediated hypothalamus to improve bone metabolism.
METHODS: A computer-based search of CNKI and PubMed databases was performed for relevant articles published from January 1983 to December 2021 with “exercise; hypothalamus; bone metabolism” as keywords both in Chinese and English. The documents that did not meet the inclusion criteria were excluded, and the 72 selected documents were summarized.
RESULTS AND CONCLUSION: The hypothalamus is the key to regulating the body’s physiological activity and the downstream of the hypothalamus-pituitary-target gland axis plays an important regulatory roleto influence hormone secretion, such as neuropeptide Y, leptin, osteocalcin and calcitonin, thus regulating regulatory factors and signaling pathways for bone metabolism, and further improving common bone diseases, such as osteoporosis. In recent years, the bone-building effect mediated by “brain-bone” crosstalk has received widespread attention in medicine, biology and sports science, but its specific occurrence and mechanism of action are still under investigation. Exercise activates bone metabolic signaling pathways through mechanical force stimulation and conduction of intracellular electrical signals.
Key words: exercise, hypothalamus, bone metabolism, brain-bone crosstalk, protein, molecule, pathway, bone health